Publications
You can also find these articles on my Google Scholar profile.
Bold indicates first-authorship. * indicates shared first-authorship. ^ indicates senior authorship.
Selected Publications
• Kim H, Kim S, Wade T, … Luebeck J^, Verhaak RGW. “Mapping extrachromosomal DNA amplifications during cancer progression.” Nature Genetics. 2024.
• Noorani I*, Luebeck J*, Rowan A, et al. “Oncogenic extrachromosomal DNA identification using whole-genome sequencing from formalin-fixed glioblastomas” Ann Oncol. 2024.
• Luebeck J, Ng AWT, Galipeau PC, et al. “Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus” Nature. 2023.
• Pang J*, Nguyen NP*, Luebeck J*, et al. “Extrachromosomal DNA in HPV-mediated oropharyngeal cancer drives diverse oncogene transcription.” Clinical Cancer Research. 2021.
• Dehkordi SR*, Luebeck J*, Bafna V. “FaNDOM: Fast Nested Distance-Based Seeding of Optical Maps.” Cell Patterns. 2021.
• Luebeck J, Coruh C, Dehkordi SR, et al. “Integrated analysis of NGS and optical mapping resolves the complex structures of focal amplifications in cancer.” Nature Communications. 2020.
All publications
• Dehkordi SR, Wong ITL, Ni J, Luebeck J, et al. “Breakage fusion bridge cycles drive high oncogene number with moderate intratumoural heterogeneity.” Nature Communications. 2025.
• Pradella D, Zhang M, Gao R, … Luebeck J, … Ventura A. “Engineered extrachromosomal oncogene amplifications promote tumorigensis.” Nature. 2024.
• Bailey C, Pich O, Thol K, Watkins TBK, Luebeck J, et al. “Origins and Impact of Extrachromosomal DNA.” Nature. 2024.
• Hung KL, Jones MG, Wong ITL, Curtis EJ, Lange JT, He BJ, Luebeck J, et al. “Coordinated inheritance of extrachromosomal DNAs in cancer cells.” Nature. 2024.
• Tang J, Weiser NE, Wang G, … Luebeck J, … Chang HY. ““Enhancing transcription replication conflict targets ecDNA positive cancers.” Nature. 2024.
• Kim H, Kim S, Wade T, … Luebeck J^, Verhaak RGW. “Mapping extrachromosomal DNA amplifications during cancer progression.” Nature Genetics. 2024.
• Rose JC, Belk JA, Wong ITL, Luebeck J, et al. “Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair” Cancer Discovery. 2024.
• Zhu K, Jones MG, Luebeck J, et al. “CoRAL accurately resolves extrachromosomal DNA genome structures with long-read sequencing” Genome Research. 2024.
• Lin MS, Jo SY, Luebeck J, et al. “Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors” eLife. 2024.
• Noorani I*, Luebeck J*, Rowan A, et al. “Oncogenic extrachromosomal DNA identification using whole-genome sequencing from formalin-fixed glioblastomas” Ann Oncol. 2024.
• Chapman OS, Luebeck J, Sridhar S, et al. “Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma” Nature Genetics. 2023.
• Agustinus A, Al-Rawi D, Dameracharla B, Raviram R, Jones BSCL, Stransky S, Scipioni L, Luebeck J, et al. “Epigenetic dysregulation from chromosomal transit in micronuclei” Nature. 2023.
• Raviram R, Raman A, Preissl S, Ning J, Wu S, Koga T, Zhang K, Brennan CW, Zhu C, Luebeck J, et al. “Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity” PNAS. 2023.
• Luebeck J, Ng AWT, Galipeau PC, et al. “Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus” Nature. 2023.
• Hung KL, Luebeck J, Dehkordi SR, et al. “Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH” Nature Genetics. 2022.
• Javadzadeh S, Rajkumar U, Nguyen N, Sarmashghi S, Luebeck J, Shang J, Bafna V. “FastViFi: Fast and accurate detection of (Hybrid) Viral DNA and RNA.” NAR Genomics and Bioinformatics. 2022.
• Bergstrom EN, Luebeck J, Petljak M, et al. “Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA.” Nature. 2022.
• Song K, Minami JK, Huang A, Dehkordi SR, Lomeli SH, Luebeck J, et al. “Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in overcoming targeted therapy dosage challenges.” Cancer Discovery. 2022.
• Hung KL, Yost KE, Xie L, Shi Q, Helmsauer K, Luebeck J, et al. “ecDNA hubs drive cooperative intermolecular oncogene expression.” Nature. 2021.
• Pang J*, Nguyen NP*, Luebeck J*, et al. “Extrachromosomal DNA in HPV-mediated oropharyngeal cancer drives diverse oncogene transcription.” Clinical Cancer Research. 2021.
• Dehkordi SR*, Luebeck J*, Bafna V. “FaNDOM: Fast Nested Distance-Based Seeding of Optical Maps.” Cell Patterns. 2021.
• Luebeck J, Coruh C, Dehkordi SR, et al. “Integrated analysis of NGS and optical mapping resolves the complex structures of focal amplifications in cancer.” Nature Communications. 2020.
• Kim H, Nguyen N, Turner K, Wu S, Gujar A, Luebeck J, et al. “Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.” Nature Genetics. 2020.
• Rocca C, Rainaldi J, Sharma J, Shi Y, Haquang J, Luebeck J, Mali P, Cherqui S. “CRISPR/Cas9 gene editing of hematopoietic stem cells from patients with Friedreich’s ataxia.” Molecular Therapy – Methods & Clinical Development. 2020.
• Rajkumar U, Turner K, Luebeck J, et al. “EcSeg: Semantic Segmentation of Metaphase Images Containing Extrachromosomal DNA.” iScience. 2019.
• Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, et al. “Circular ecDNA promotes accessible chromatin and high oncogene expression.” Nature. 2019. (Publication subsequently featured in a New York Times article by Carl Zimmer).
• Deshpande V, Luebeck J, Nguyen ND, et al. “Exploring the landscape of focal amplifications in cancer using AmpliconArchitect.” Nature Communications. 2019.
• Nguyen ND, Deshpande V, Luebeck J, Mischel PS, Bafna V. “ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer.” Nucleic Acids Research. 2018.
• Zhao D, Badur MG, Luebeck J, et al. “Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis.” Molecular Cell. 2018.
• Gray VE, Hause RJ, Luebeck J, Shendure J, Fowler DM. “Quantitative Missense Variant Effect Prediction Using Large-Scale Mutagenesis Data.” Cell Systems. 2018.
• Shen JP, Zhao D, Sasik R, Luebeck J, et al. “Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.” Nature Methods. 2017.